Hemi-protonated
WebThese results reveal that formation of only two hemi-protonated C:C + base pairs can lead to an apparent pK a comparable to those of cytosine rich sequences. Although the number of hemi-protonated base pairs is important for stability, capping interactions are also determinant for i-motif formation at slightly acidic or neutral pH. Web8 mei 2024 · We have also demonstrated the versatile ability of this i-motif ligand, i.e., the affinity of C343 towards both intermolecular and intramolecular i-motif DNA differing in the chain lengths, molecularity and sizes, which is observed in various oncogene promoters.
Hemi-protonated
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Web31 jan. 2024 · i-Motifs are four-stranded DNA structures formed from sequences rich in cytosine, held together by hemi-protonated cytosine-cytosine base pairs. These structures have been utilized extensively as pH-switches in DNA-based nanotechnology. Recently there has been an increasing interest in i-motif struc … Web18 jan. 2024 · i-Motif (the name stems from “intercalated”), also known as i-DNA, is a pH-dependent four-stranded nucleic acid structure formed by cytosine-rich sequences via …
Web19 sep. 2024 · The i-motif represents a paradigmatic example of the wide structural versatility of nucleic acids. In remarkable contrast to duplex DNA, i-motifs are four … Web2 feb. 2024 · The detection and removal of heavy metal species in aquatic environments is of continued interest to address ongoing efforts in water security. This study was focused on the preparation and characterization of aniline grafted chitosan (CS-Ac-An), and evaluation of its adsorption properties with Cu(II) under variable conditions. Materials …
Web16 sep. 2024 · Generally, to favour the formation of hemi-protonated C·C + base pairs, iM structures are studied in vitro in acidic solutions and possibly in the presence of sodium or potassium ions, whose concentrations vary from 10 to 150 mM. Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆
Web23 dec. 2024 · I-Motif is a tetrameric cytosine-rich DNA structure with hemi-protonated cytosine: cytosine base pairs. Recent evidence showed that i-motif structures in human cells play regulatory roles in the genome. Therefore, characterization of novel i-motifs and investigation of their functional implication a …
Webi-Motif (the name stems from “intercalated”), also known as i-DNA, is a pH-dependent four-stranded nucleic acid structure formed by cytosine-rich sequences via hemi-protonated and intercalated C C+base pairs. total amount of fresh water on earthWebHemi-Protonated Cytosines i-Motifs are four-stranded secondary structures comprised of two parallel-stranded DNA duplexes zipped together in an antiparallel orientation by intercalated, hemi-protonated cytosine–cytosine base pairs (Fig. 2) (Gehring et al. 1993). The building block of i-motifs is the CC+ base pair, and it is formed by the planar total amount of force on an objectWeb24 mrt. 2024 · i-motifs are noncanonical DNA structures formed via the stack of intercalating hemi-protonated C +: C base pairs in C-rich DNA strands and play essential roles in the regulation of gene expression.Here, we systematically investigated the impacts of K + on i-motif DNA folding using different buffer systems. We found that i-motif structures display … total amount of hemoglobin in dogsWeb1 jun. 2024 · i-Motifs are quadruplex DNA structures formed from sequences rich in cytosine and held together by intercalated, hemi-protonated cytosine–cytosine base pairs. These sequences are prevalent in gene promoter regions and may play a role in gene transcription. total amount of expensesWeb18 sep. 2013 · The transient IR absorption spectrum for UV-excited i-motif DNA is reported for the first time and found to possess complex dynamics pointing to multiple decay … total amount of gold mined in historyWeb8 mei 2024 · Abstract. Here, we have explored the light-up property of coumarin 343 (C343) selectively towards various i-motif DNAs based on the recognition of hemi-protonated … total amount of manufacturing overhead costWeb24 mrt. 2024 · i-motifs are noncanonical DNA structures formed via the stack of intercalating hemi-protonated C +: C base pairs in C-rich DNA strands and play … total amount of money savings and investments